Purpurogallin: in vivo evidence of a novel and effective cardioprotector.

Abstract

We observed that purpurogallin (PPG) which is a flavonoid markedly protects the rabbit against myocardial ischemia-reperfusion injury. In rabbits undergoing 1-h ligation of the anterior ventricular coronary artery, a bolus infusion of PPG was introduced into the post-ischemic heart immediately before 3-h reperfusion. Against negligible necrosis in 6 sham-operated controls, and 41.7 (SD 11.3)% necrosis in the area at risk for the placebo control group (n = 14 animals), the PPG-treated groups (n = 6, 6, 14) had a necrosis of 26.8 (6.4)%, 10.8 (3.5)%, and 11.7 (5.2)% at doses of 2.5, 5, and 10 mumol/kg, respectively (each with p < 0.01 vs control value). By comparison, infusion of Trolox (a vitamin E analogue) at 5 mumol/kg produced a higher necrosis of 17.7 +/- 7.2% (n = 6, p < 0.05 vs value obtained from 5 mumol/kg PPG-treated group) in the same model. Note that myocardial necrosis was estimated by tetrazolium-based histochemistry and confirmed by light and transmission electron microscopies. These data support our contention that PPG is an effective cardioprotector, whose mechanism of action will be reported separately.

• Authors: T W Wu, J Wu, L H Zeng, J X Au, D Carey, K P Fung
• Journal: Life sciences (Life Sci) Vol. 54 Issue 2 Pg. PL23-8 ( 1994) ISSN: 0024-3205 [Print] Netherlands
• PMID: 8277814 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Benzocycloheptenes
• purpurogallin

Topics

• Analysis of Variance
• Animals
• Antioxidants (therapeutic use)
• Benzocycloheptenes (therapeutic use)
• Dose-Response Relationship, Drug
• Heart (drug effects)
• Myocardial Reperfusion Injury (pathology, prevention & control)
• Myocardium (pathology)
• Necrosis
• Rabbits