HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Gastrointestinal transit in cirrhotic patients: effect of hepatic encephalopathy and its treatment.

Abstract
Chronic hepatic encephalopathy is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides. The precise pathophysiology of chronic hepatic encephalopathy in individual cases is highly variable, although ammonia toxicity and production of neurotransmitterlike substances in the gut have been proposed to contribute to the overall syndrome of chronic hepatic encephalopathy. The support for this hypothesis is based on the empiric observation that reduction in protein intake, a catharsis or both are effective treatments for chronic hepatic encephalopathy. This study was performed to evaluate the effect of mild subclinical and low-grade (grade 0 to 1) chronic hepatic encephalopathy on gastric emptying and oral-cecal transit times. Thirty patients were studied. Ten had no evidence of chronic hepatic encephalopathy, as determined with a battery of neuropsychiatric studies (group 1); 10 had subclinical hepatic encephalopathy, as judged on the basis of abnormal neuropsychiatric test performance but normal neurological examination (group 2); and 10 had grade 1 hepatic encephalopathy. Each underwent a liquid gastric emptying study and a lactulose oral-cecal transit time study. No significant differences between groups were evident in the results of the gastric emptying studies. In contrast, the time required for a lactulose load to reach the cecum was significantly greater in the patients with hepatic encephalopathy (p < 0.01) and increased as a function of the hepatic encephalopathy grade.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsD H Van Thiel, S Fagiuoli, H I Wright, M C Chien, J S Gavaler
JournalHepatology (Baltimore, Md.) (Hepatology) Vol. 19 Issue 1 Pg. 67-71 (Jan 1994) ISSN: 0270-9139 [Print] UNITED STATES
PMID8276369 (Publication Type: Journal Article)
Chemical References
  • Dietary Proteins
  • Neomycin
  • Ammonia
Topics
  • Adult
  • Ammonia (metabolism)
  • Chronic Disease
  • Dietary Proteins (administration & dosage)
  • Female
  • Gastric Emptying
  • Gastrointestinal Transit
  • Hepatic Encephalopathy (etiology, physiopathology, therapy)
  • Humans
  • Liver Cirrhosis (complications, metabolism, physiopathology)
  • Male
  • Middle Aged
  • Neomycin (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: