Effects of semotiadil fumarate, a novel calcium antagonist, on blood pressure and heart rate in conscious spontaneously hypertensive rats.

Abstract

The acute antihypertensive effects of orally administered semotiadil, a novel calcium antagonist, were compared with those of nifedipine and diltiazem in conscious, unrestrained spontaneously hypertensive rats (SHRs). Semotiadil (10 and 30 mg/kg) produced a dose-dependent hypotension that persisted for 18 hr at 30 mg/kg. Diltiazem (30 and 100 mg/kg) and nifedipine (1 and 3 mg/kg) also exhibited hypotension dose-dependently, but their durations of actions were shorter than that of semotiadil. Semotiadil caused a slight increase in heart rate, while diltiazem and nifedipine caused a bradycardia and a marked tachycardia, respectively. These results suggest that semotiadil has a beneficial property as an antihypertensive drug.

• Authors: A Kanda, H Hashimoto
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 63 Issue 1 Pg. 121-4 (Sep 1993) ISSN: 0021-5198 [Print] Japan
• PMID: 8271524 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• Thiazoles
• sesamodil
• Diltiazem
• Nifedipine

Topics

• Animals
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology, therapeutic use)
• Diltiazem (pharmacology)
• Dose-Response Relationship, Drug
• Heart Rate (drug effects)
• Hypertension (drug therapy, physiopathology)
• Male
• Nifedipine (pharmacology)
• Rats
• Rats, Inbred SHR
• Thiazoles (pharmacology, therapeutic use)