Effect of arginine-enriched total parenteral nutrition on the host-tumor interaction in cancer-bearing rats.
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| Abstract |
By using a transplantable Yoshida sarcoma in a rat total parenteral nutrition model, we measured the effectiveness of an arginine-enriched amino acid solution (AI-82) in terms of leucine kinetics and nitrogen balance as indicators of host-tumor nutrition interaction compared with that of a conventional amino acid solution (Proteamin12). When tumor-bearing rats received isocaloric total parenteral nutrition solutions for 7 days, AI-82 significantly improved host nitrogen balance and significantly decreased the tumor-nitrogen trap throughout the experimental period. Leucine kinetics of whole body and tissues were also determined by a 4-hour continuous infusion of each total parenteral nutrition solution containing 14C-leucine. Significantly increased whole-body leucine oxidation (p < .01) without an increase in leucine release from normal tissues was observed in the AI-82 group. Total incorporation of 14C-leucine into whole muscle was significantly elevated (p < .05) without changes in muscle protein degradation in the AI-82 group. In the whole tumor, AI-82 tended to decrease total incorporation of 14C-leucine, but there was no difference in leucine release caused by protein breakdown between the two groups. These findings suggest that AI-82 can improve the nutritional status of the host over that of the tumor.
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| Authors | T Oka, K Ohwada, M Nagao, K Kitazato |
| Journal | JPEN. Journal of parenteral and enteral nutrition (JPEN J Parenter Enteral Nutr) 1993 Jul-Aug Vol. 17 Issue 4 Pg. 375-83 ISSN: 0148-6071 [Print] United States |
| PMID | 8271364 (Publication Type: Comparative Study, Journal Article) |
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