A double-blind clinical trial of kamalahar, an indigenous compound preparation, in acute viral hepatitis.

Abstract

BACKGROUND:

Kamalahar is an indigenous preparation reported to be beneficial in acute viral hepatitis.

AIMS:

To evaluate the efficacy of Kamalahain acute viral hepatitis in a double-blind, placebo-controlled study.

METHODS:

Fifty two patients with acute viral hepatitis were randomized to receive either Kamalahar 500 mg or a matched placebo three times a day for 15 days. Forty four patients (Kamalahar 20; placebo 24) completed the trial.

RESULTS:

Improvement in clinical signs was more marked with Kamalahar compared to placebo. The fall in serum bilirubin (p < 0.001), SGPT (p < 0.001) and serum alkaline phosphatase (p < 0.005) at day 15 was significantly greater with the drug. No significant side effects were observed.

CONCLUSION:

Kamalahar offers therapeutic promise in acute viral hepatitis.

• Authors: D G Das
• Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology (Indian J Gastroenterol) Vol. 12 Issue 4 Pg. 126-8 (Oct 1993) ISSN: 0254-8860 [Print] India
• PMID: 8270290 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Kamalahar
• Plant Extracts

Topics

• Acute Disease
• Adolescent
• Adult
• Double-Blind Method
• Female
• Hepatitis, Viral, Human (drug therapy)
• Humans
• Male
• Medicine, Ayurvedic
• Middle Aged
• Plant Extracts (therapeutic use)