Antitumor activity of paramylon on sarcoma-180 in mice.

Abstract

The antitumor effect of reserve polysaccharide, paramylon, from Euglena gracilis on the transplantable sarcoma-180 was examined in mice. This polysaccharide had an effect similar to that of lentinan. Paramylon, in a dose of 1 mug/g body weight, injected intraperitoneally 24 hr after tumor implantation had an inhibitory effect on the tumor growth, although without causing complete regression of the tumor. Alkaline-treated paramylon had a similar effect but at a smaller concentration than the native one. The inhibitory activity was not lost when the paramylon preparation was treated with pronase, DNase, or RNase. The antitumor effect might be a lymphocyte-mediated process. In tumors that were regressing after treatment, there was extensive outpouring of lymphoid cells with plasma cells and macrophages. A test conducted using paramylon ruled out the possibility of an interferon-mediated inhibiotry effect on tumor growth.

• Authors: L A Quesada, E S de Lustig, L R Marechal, E Belocopitow
• Journal: Gan (Gan) Vol. 67 Issue 3 Pg. 455-9 (Jun 1976) ISSN: 0016-450X [Print] Japan
• PMID: 826442 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antineoplastic Agents
• Glucans
• Polysaccharides
• Lentinan
• paramylon

Topics

• Animals
• Antineoplastic Agents
• Chick Embryo
• Euglena gracilis
• Glucans
• Lentinan (therapeutic use)
• Mice
• Polysaccharides (therapeutic use)
• Sarcoma 180 (drug therapy, pathology)
• Time Factors