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Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissue of 'anergic' tuberculosis patients.

Abstract
Lymphocyte-transformation responses to mycobacterial antigens have been studied, using paired blood and lymph node samples from 'normal' Ugandans, (hernia repairs or orthopaedic cases) or from patients with tuberculosis, Mycobacterium ulcerans infection, or injection abscesses. The results suggest that in some individuals, antigen reactive cells, although absent from the periphery, may be demonstrable in the lymph nodes. This phenomenon is most striking in skin-test negative tuberculosis patients.
AuthorsG A Rook, J W Carswell, J L Stanford
JournalClinical and experimental immunology (Clin Exp Immunol) Vol. 26 Issue 1 Pg. 129-32 (Oct 1976) ISSN: 0009-9104 [Print] England
PMID826362 (Publication Type: Journal Article)
Chemical References
  • Antigens, Bacterial
Topics
  • Antigen-Antibody Reactions
  • Antigens, Bacterial
  • Humans
  • Hypersensitivity
  • In Vitro Techniques
  • Lymph Nodes (immunology)
  • Lymphocyte Activation
  • Mycobacterium Infections (immunology)
  • Mycobacterium tuberculosis (immunology)
  • Skin Tests
  • Tuberculosis (immunology)

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