Effect of hydroxypropyl-beta-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis.

Abstract

The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl beta-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses > or = 30 mg/kg/day solubilized in hydroxypropyl-beta-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.

• Authors: J S Hostetler, L H Hanson, D A Stevens
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 32 Issue 3 Pg. 459-63 (Sep 1993) ISSN: 0305-7453 [Print] England
• PMID: 8262868 (Publication Type: Journal Article)

Chemical References

• Cyclodextrins
• Excipients
• Solutions
• beta-Cyclodextrins
• 2-Hydroxypropyl-beta-cyclodextrin
• Itraconazole
• Polyethylene Glycols

Topics

• 2-Hydroxypropyl-beta-cyclodextrin
• Animals
• Cryptococcosis (drug therapy, microbiology)
• Cyclodextrins (pharmacology)
• Excipients
• Female
• Itraconazole (administration & dosage, pharmacology)
• Mice
• Polyethylene Glycols
• Solutions
• beta-Cyclodextrins