Carcinogens stimulate phosphorylation of ethanolamine derived from increased hydrolysis of phosphatidylethanolamine in C3H/101/2 fibroblasts.

Many human tumors contain high concentrations of ethanolamine phosphate (EtnP). An important question is whether increased formation of EtnP is merely the consequence of cell transformation, or is it associated with the process of carcinogenesis. Here we show that in C3H/10T1/2 embryonic fibroblasts, an established cellular model for the study of carcinogenesis, the environmental carcinogens, 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) (0.1-1 microgram/ml concentration; 24 h treatment), stimulate phosphorylation of ethanolamine derived from increased hydrolysis of phosphatidylethanolamine. The results suggest that increased formation of EtnP is associated with the early stages of carcinogenesis. This observation may have prognostic value.
AuthorsZ Kiss, K S Crilly, W H Anderson
JournalFEBS letters (FEBS Lett) Vol. 336 Issue 1 Pg. 115-8 (Dec 20 1993) ISSN: 0014-5793 [Print] NETHERLANDS
PMID8262191 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
  • Ethanolamines
  • Phosphatidylethanolamines
  • Phosphorylcholine
  • Benzo(a)pyrene
  • 9,10-Dimethyl-1,2-benzanthracene
  • phosphorylethanolamine
  • Phosphotransferases (Alcohol Group Acceptor)
  • ethanolamine kinase
  • 9,10-Dimethyl-1,2-benzanthracene (pharmacology)
  • Animals
  • Benzo(a)pyrene (pharmacology)
  • Carcinogens (pharmacology)
  • Cell Line
  • Ethanolamines (metabolism)
  • Hydrolysis
  • Mice
  • Mice, Inbred C3H
  • Phosphatidylethanolamines (metabolism)
  • Phosphorylation (drug effects)
  • Phosphorylcholine (metabolism)
  • Phosphotransferases (Alcohol Group Acceptor) (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: