Thrombocytic, haemostatic and fibrinolytic quantities were investigated in 47 patients with
cerebral infarction and 34 patients with cerebral haemorrhage. Sixteen of the
infarction patients and ten patients of the haemorrhage group were on
acetylsalicylic acid medication. Of the remaining 55 patients without acetylsalicylic medication 21/31 = 67.7% of the patients in the
infarction group and 9/24 = 37.5% of the patients in the
bleeding group had unphysiologically enhanced
ADP-induced platelet aggregation. With regard to the coagulation and fibrinolysis markers no significant differences were found between the two groups. In both groups, coagulation activity markers (
fibrin monomer and
thrombin-
antithrombin III), as well as D-dimers were significantly higher than in controls in a high proportion of cases. In 5/47 of the
infarction patients and in 3/34 of the haemorrhage patients the
fibrin monomer levels were elevated to such an extent, that it can be considered as low grade
disseminated intravascular coagulation. In the cerebral haemorrhage group, 80.3% of the patients who subsequently died showed a significantly enhanced
fibrin monomer concentration, compared with 28.6% of those who survived. The corresponding frequencies for
D-dimer were 100% compared with 66.7%. In the
cerebral infarction group, the only analytical quantity showing a significant difference between patients with a fatal outcome and those with a non-fatal outcome was
ADP (2 mumol/l) induced platelet aggregation (83.3% in the fatal group, 40.0% in the non-fatal group).