Abstract |
Haloperidol, moperone, pipamperone and bromperidol were found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection ( SID). The calibration curves using moperone as internal standard were linear in the range of 0.4-4 pmol on column for haloperidol, pipamperone, and bromperidol. The detection limit of the drugs was about 0.1 pmol on column. For their actual determination with forensic samples, a detailed procedure for their extraction from human whole blood and urine was established with Sep-Pak C18 cartridges. The recovery of the 4 drugs, which had been added to whole blood and urine, was more than 90%. Haloperidol in whole blood and urine of a schizophrenic patient, who had been administered with this drug (3 mg/day p.o.), could be quantitated by the present GC- SID, and the levels were 7.18 and 43.2 pmol/ml, respectively.
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Authors | H Seno, T Kumazawa, A Ishii, K Sato, O Suzuki |
Journal | Nihon hoigaku zasshi = The Japanese journal of legal medicine
(Nihon Hoigaku Zasshi)
Vol. 47
Issue 5
Pg. 367-71
(Oct 1993)
ISSN: 0047-1887 [Print] Japan |
PMID | 8258900
(Publication Type: Journal Article)
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Chemical References |
- Butyrophenones
- pipamperone
- Haloperidol
- bromperidol
- moperone
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Topics |
- Butyrophenones
(analysis, blood, urine)
- Chromatography, Gas
(methods)
- Haloperidol
(analogs & derivatives, analysis)
- Humans
- Schizophrenia
(metabolism)
- Sensitivity and Specificity
- Surface Properties
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