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Management of hepatic encephalopathy with oral zinc supplementation: a long-term treatment.

AbstractOBJECTIVES:
The effect of long-term oral zinc supplementation, in addition to standard therapy (protein-restricted diet and lactulose) on recurrent hepatic encephalopathy, was assessed in a double-blind study.
METHODS:
Ninety cirrhotic patients with stable recurrent hepatic encephalopathy, after following a one month period of standard therapy, were randomized to receive oral zinc acetate supplementation (600 mg/day) in addition to standard therapy or to continue only standard therapy (a diet containing 0.8 g/kg/day of protein and 90 g/day of lactulose) for six months. Psychometric tests, NCT (number correction test) and PSE (portal-systemic encephalopathy) Index, were used to evaluate the degree of hepatic encephalopathy, both at the beginning and the end of each treatment period.
RESULTS:
Oral zinc supplementation in addition to standard therapy was able to normalize serum zinc levels. The patients who never showed clinical signs of hepatic encephalopathy during the trial were 88.6% in zinc-group and 86% in only standard therapy group. Psychometric tests, NCT and PSE Index, were statistically better than basal values either in zinc-group or in only standard therapy group.
CONCLUSIONS:
Final values of psychometric tests were better in zinc-group than only standard therapy group but the differences were not statistically significant.
AuthorsG Bresci, G Parisi, S Banti
JournalThe European journal of medicine (Eur J Med) 1993 Aug-Sep Vol. 2 Issue 7 Pg. 414-6 ISSN: 1165-0478 [Print] FRANCE
PMID8258031 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Acetates
  • Zinc
  • Acetic Acid
Topics
  • Acetates (administration & dosage)
  • Acetic Acid
  • Administration, Oral
  • Double-Blind Method
  • Female
  • Hepatic Encephalopathy (blood, drug therapy, etiology, psychology)
  • Humans
  • Liver Cirrhosis (complications)
  • Male
  • Middle Aged
  • Psychological Tests
  • Time Factors
  • Zinc (blood)

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