205Bi/206Bi cyclotron production from Pb-isotopes for absorption studies in humans.

Abstract

Pb(p, xn) thick target excitation functions were measured in the energy range 10-38 MeV in order to optimize the production of isotopically pure radiobismuth from natPb, 206Pb, and 207Pb. Additionally, the decay of Po-isotopes from deuteron irradiation of natural bismuth (209Bi) was exploited for radiobismuth production. 205Bi was produced from 206Pb at 20 MeV with only 2% of 206Bi at 4 weeks post irradiation. Bismuth compounds as used in the treatment of peptic ulcer were labeled with 205Bi for absorption studies in animals and subjects.

• Authors: R Fischer, J Wendel, B Dresow, V Bechtold, H C Heinrich
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 44 Issue 12 Pg. 1467-72 (Dec 1993) ISSN: 0969-8043 [Print] England
• PMID: 8257965 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radioisotopes
• Bismuth

Topics

• Bismuth (blood, pharmacokinetics, urine)
• Cyclotrons
• Feces (chemistry)
• Humans
• Pilot Projects
• Radioisotopes (blood, pharmacokinetics, urine)