Effects of long-term, low-fat diet on plasma apo E in familial LCAT deficiency.
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| Abstract |
To study the metabolic abnormalities in familial lecithin-cholesterol acyltransferase (LCAT) deficiency, the effects of a long-term, low-fat diet and LCAT replacement therapy on plasma lipids and apolipoproteins were investigated in a patient with LCAT deficiency. The patient had elevated triglycerides (TG, 543.7 mg/dl) and phospholipids (PL, 350.3 mg/dl) and normal total cholesterol (TC, 206.9 mg/dl). Change to a low-fat diet reduced TC and TG by 20% and 75%, respectively. These reductions occurred mainly in the d < 1.006 fraction. At baseline, the patient had normal apolipoprotein B (apo B), low apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II) and elevated apolipoprotein E (apo E). Long-term treatment with a low-fat diet increased plasma apoA-I and decreased apo E. However, urinary protein excretion did not change throughout the observed period. LCAT replacement with fresh frozen plasma (FFP) after the low-fat diet further reduced plasma apo E to the normal range. These results indicate that the elevated plasma apo E in LCAT deficiency was related not only to the lack of LCAT in the plasma, but also to fat intake. A low-fat diet may be effective in correcting lipid abnormalities. Moreover, plasma apo E may be a good indicator of the efficacy of diet therapy.
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| Authors | S Homma, N Murayama, T Kodama, N Yamada, K Takahashi, Y Asano, S Hosoda, T Murase, Y Akanuma |
| Journal | Nihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 35 Issue 8 Pg. 999-1006 (Aug 1993) ISSN: 0385-2385 [Print] Japan |
| PMID | 8255012 (Publication Type: Case Reports, Journal Article) |
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