Abstract | BACKGROUND: Inhibition of prostaglandin synthesis is likely a primary mechanism for both the anti-inflammatory and ulcerogenic effects of nonsteroidal anti-inflammatory drugs ( NSAIDs). The present study examined the mechanism underlying the ability of a novel anti-inflammatory drug, tepoxalin, to suppress prostaglandin synthesis without inducing gastric mucosal injury. METHODS: RESULTS: CONCLUSIONS: The ability of tepoxalin to suppress inflammation without causing gastric mucosal injury appears to be related to its differential suppression of prostaglandin synthesis in various tissues. Compounds that selectively inhibit prostaglandin synthesis at sites of inflammation may represent a class of anti-inflammatory drugs without detrimental effects on the stomach.
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Authors | J L Wallace, D M McCafferty, L Carter, W McKnight, D Argentieri |
Journal | Gastroenterology
(Gastroenterology)
Vol. 105
Issue 6
Pg. 1630-6
(Dec 1993)
ISSN: 0016-5085 [Print] United States |
PMID | 8253339
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Prostaglandins
- Pyrazoles
- tepoxalin
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Cell Adhesion
(drug effects)
- Gastric Mucosa
(drug effects)
- Leukocytes
(drug effects, physiology)
- Male
- Organ Specificity
- Prostaglandins
(biosynthesis)
- Pyrazoles
(pharmacology, toxicity)
- Rats
- Rats, Wistar
- Stomach Ulcer
(chemically induced)
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