Plasma 19-hydroxyandrostenedione is elevated in patients with high renin essential hypertension.

Abstract

OBJECTIVES:

We have reported that 19-hydroxyandrostenedione (19-OH-A-dione) functions as an amplifier of the sodium-retaining and hypertensive action of aldosterone. We therefore measured 19-hydroxyandrostenedione in hypertensive patients.

PATIENTS AND MEASUREMENTS:

We studied 53 normal male control subjects and 63 male patients with essential hypertension (48 patients with normal renin essential hypertension and 15 patients with high renin essential hypertension). Plasma 19-OH-A-dione levels were measured by RIA.

RESULTS:

Plasma 19-OH-A-dione concentrations in control subjects and patients with normal and high renin essential hypertension were 115 +/- 46 (mean +/- SD), 112 +/- 49 and 201 +/- 79 pmol/l, respectively. Patients with high renin essential hypertension showed significantly higher 19-OH-A-dione concentrations than did control subjects. The evaluation of the correlation between plasma 19-OH-A-dione concentrations and plasma renin activity revealed that plasma 19-OH-A-dione concentrations in hypertensive subjects rose gradually with an increase in plasma renin activity. Therefore, a significant correlation was found between plasma renin activity and plasma 19-OH-A-dione (r = 0.586, P < 0.001). In contrast, in control subjects, no significant correlation was found between plasma renin activity and plasma 19-OH-A-dione (r = 0.059, P > 0.05).

CONCLUSIONS:

The secretion of 19-OH-A-dione from the adrenal cortex is under the control of the renin-angiotensin system in hypertensives but not in normotensives.

• Authors: H Sekihara, K Yonemitsu, Y Yazaki
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 39 Issue 5 Pg. 557-60 (Nov 1993) ISSN: 0300-0664 [Print] England
• PMID: 8252745 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androstenedione
• 19-hydroxy-4-androstene-3,17-dione
• Renin

Topics

• Adult
• Androstenedione (analogs & derivatives, blood)
• Humans
• Hypertension (blood)
• Male
• Middle Aged
• Radioimmunoassay
• Renin (blood)