Abstract | BACKGROUND: METHODS: RESULTS: Although rare in normal esophageal epithelium, these modified nucleosides were strongly stained in esophageal carcinoma cells. Most carcinoma cells exhibited a cytoplasmic pattern, although some cells at the infiltrating edge displayed a nuclear pattern. These modified nucleosides were intensely imaged in 11 of 12 cultured esophageal cell lines, the exception being one line that had a much longer doubling time. Using ELISA, urinary excretion of these modified nucleosides was found to be significantly higher in patients with esophageal carcinoma than in healthy subjects; such excretion correlated with carcinoma size and stage and tended to decrease after treatment. CONCLUSIONS:
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Authors | M Masuda, T Nishihira, K Itoh, M Mizugaki, N Ishida, S Mori |
Journal | Cancer
(Cancer)
Vol. 72
Issue 12
Pg. 3571-8
(Dec 15 1993)
ISSN: 0008-543X [Print] United States |
PMID | 8252470
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Pseudouridine
- 1-methyladenosine
- Adenosine
|
Topics |
- Adenosine
(analogs & derivatives, immunology, urine)
- Antibodies, Monoclonal
(immunology)
- Biomarkers, Tumor
(urine)
- Carcinoma
(chemistry, pathology, urine)
- Enzyme-Linked Immunosorbent Assay
- Esophageal Neoplasms
(chemistry, pathology, urine)
- Humans
- Immunohistochemistry
- Neoplasm Staging
- Pseudouridine
(immunology, urine)
- Tumor Cells, Cultured
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