A comparative burn wound model in the New Yorkshire pig for the histopathological evaluation of local therapeutic regimens: silver sulfadiazine cream as a standard.

Abstract

A standard burn wound model was developed in the pig to enable evaluation of histopathological parameters of wound healing under different circumstances. Wounds on one flank were treated with silver sulfadiazine 1% cream (SSD, Flammazine-Duphar), which is a standard treatment. On identical places of the contralateral side different topical agents were applied. From the SSD treated burns a typical histopathologic picture of wound healing under SSD could be derived: SSD has the potential to preserve viable dermal tissue, epidermal regeneration is rather slow and irritated, while the formation of granulation tissue is pronounced, with an abundance of myofibroblasts.

• Authors: M J Hoekstra, P Hupkens, R P Dutrieux, M M Bosch, T A Brans, R W Kreis
• Journal: British journal of plastic surgery (Br J Plast Surg) Vol. 46 Issue 7 Pg. 585-9 (Oct 1993) ISSN: 0007-1226 [Print] England
• PMID: 8252267 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Silver Sulfadiazine

Topics

• Animals
• Burns (drug therapy, pathology)
• Disease Models, Animal
• Granulation Tissue (pathology)
• Silver Sulfadiazine (therapeutic use)
• Swine
• Time Factors
• Wound Healing (drug effects)