Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells.

Abstract

Chromone, flavone and xanthone analogues of geiparvarin (1) are described. Compounds 2a and 2b are more active in inhibiting the proliferation of F10 metastatic murine melanoma cells. In particular, 2a is 13 times more active at microM concentration after 48 h exposure.

• Authors: P Valenti, P Da Re, A Rampa, P Montanari, M Carrara, L Cima
• Journal: Anti-cancer drug design (Anticancer Drug Des) Vol. 8 Issue 5 Pg. 349-60 (Oct 1993) ISSN: 0266-9536 [Print] United States
• PMID: 8251042 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Chromones
• Coumarins
• Flavones
• Flavonoids
• Xanthenes
• Xanthones
• xanthone
• geiparvarin
• flavone

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Chromones (chemistry)
• Coumarins (chemistry, pharmacology)
• Drug Screening Assays, Antitumor
• Flavones
• Flavonoids (chemistry)
• Melanoma, Experimental (drug therapy, ultrastructure)
• Mice
• Mice, Inbred C57BL
• Microscopy, Electron, Scanning
• Structure-Activity Relationship
• Tumor Cells, Cultured
• Xanthenes (chemistry)
• Xanthones