Abstract |
Effects of dietary vitamin E supplementation in rats were studied to determine whether or not they have a higher tolerance against cardiac ischemia-reperfusion injury using the working or Langendorff heart systems. Also, dihydrolipoic acid, recently reported to have potent antioxidant properties and accelerate vitamin E recycling of membrane in vitro, was perfused into the heart model systems to investigate its in vivo relationship with vitamin E. Tissue vitamin E content was increased by vitamin E feeding, but heart preparations did not show any improved functional recovery. Control hearts perfused with dihydrolipoic acid also did not show any improvement. However, a synergistic response is observed with the combination of dihydrolipoic acid perfusion and high dietary vitamin E using both perfusion systems in improvement of cardiac recovery. These results indicate that a high concentration of myocardial vitamin E does not increase tolerance to ischemia-reperfusion injury by itself, but, the combination of exogenous dihydrolipoic acid and high endogenous vitamin E can produce synergistic protective effects on recovery from ischemia during reperfusion.
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Authors | N Haramaki, L Packer, H Assadnazari, G Zimmer |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 196
Issue 3
Pg. 1101-7
(Nov 15 1993)
ISSN: 0006-291X [Print] United States |
PMID | 8250867
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biomarkers
- Vitamin E
- Thioctic Acid
- dihydrolipoic acid
- L-Lactate Dehydrogenase
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Topics |
- Analysis of Variance
- Animals
- Biomarkers
(analysis)
- Coronary Circulation
(drug effects)
- Food, Fortified
- Hypoxia
- In Vitro Techniques
- L-Lactate Dehydrogenase
(analysis)
- Male
- Myocardial Ischemia
(physiopathology)
- Myocardium
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(physiopathology, prevention & control)
- Thioctic Acid
(administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
- Time Factors
- Vitamin E
(administration & dosage, pharmacology, therapeutic use)
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