HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.

Abstract
Effects of dietary vitamin E supplementation in rats were studied to determine whether or not they have a higher tolerance against cardiac ischemia-reperfusion injury using the working or Langendorff heart systems. Also, dihydrolipoic acid, recently reported to have potent antioxidant properties and accelerate vitamin E recycling of membrane in vitro, was perfused into the heart model systems to investigate its in vivo relationship with vitamin E. Tissue vitamin E content was increased by vitamin E feeding, but heart preparations did not show any improved functional recovery. Control hearts perfused with dihydrolipoic acid also did not show any improvement. However, a synergistic response is observed with the combination of dihydrolipoic acid perfusion and high dietary vitamin E using both perfusion systems in improvement of cardiac recovery. These results indicate that a high concentration of myocardial vitamin E does not increase tolerance to ischemia-reperfusion injury by itself, but, the combination of exogenous dihydrolipoic acid and high endogenous vitamin E can produce synergistic protective effects on recovery from ischemia during reperfusion.
AuthorsN Haramaki, L Packer, H Assadnazari, G Zimmer
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 196 Issue 3 Pg. 1101-7 (Nov 15 1993) ISSN: 0006-291X [Print] United States
PMID8250867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Biomarkers
  • Vitamin E
  • Thioctic Acid
  • dihydrolipoic acid
  • L-Lactate Dehydrogenase
Topics
  • Analysis of Variance
  • Animals
  • Biomarkers (analysis)
  • Coronary Circulation (drug effects)
  • Food, Fortified
  • Hypoxia
  • In Vitro Techniques
  • L-Lactate Dehydrogenase (analysis)
  • Male
  • Myocardial Ischemia (physiopathology)
  • Myocardium (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury (physiopathology, prevention & control)
  • Thioctic Acid (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
  • Time Factors
  • Vitamin E (administration & dosage, pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: