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[Protective action of blumeatin against experimental liver injuries].

Abstract
Blumeatin (Blu, 5,3',5'-trihydroxy-7-methoxy-dihydro-flavone) was first isolated from Blumea balsamifera DC by Department of Chemistry, Sunyatsen University of China. Blu ip inhibited the increase of serum alanine aminotransferase (AAT) and liver triglyceride and increased serum triglyceride, beta-lipoprotein, and liver glycogen content in CCl4-intoxicated rats. Histological lesions of liver were less severe than those of hepatic injury control. Blu ip 0.65 and 3.25 mg.kg-1 inhibited the increase of serum AAT and hepatic TG in thioacetamide (TAA)-intoxicated mice. Blu ip shortened the pentobarbital sleeping time in CCl4-intoxicated mice. It suggested that Blu could protect liver against injury induced by CCl4 and TAA.
AuthorsS B Xu, W F Chen, H Q Liang, Y C Lin, Y J Deng, K H Long
JournalZhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 14 Issue 4 Pg. 376-8 (Jul 1993) ISSN: 0253-9756 [Print] CHINA
PMID8249641 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Drugs, Chinese Herbal
  • Flavonoids
  • Triglycerides
  • blumeatin
  • Thioacetamide
  • Alanine Transaminase
Topics
  • Alanine Transaminase (blood)
  • Animals
  • Carbon Tetrachloride Poisoning (prevention & control)
  • Drug-Induced Liver Injury (metabolism, prevention & control)
  • Drugs, Chinese Herbal (chemistry, therapeutic use)
  • Female
  • Flavonoids (therapeutic use)
  • Liver (metabolism, pathology)
  • Male
  • Mice
  • Rats
  • Rats, Sprague-Dawley
  • Thioacetamide
  • Triglycerides (metabolism)

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