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Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.

Abstract
Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.
AuthorsY Hayakawa, M Matsuoka, K Shin-ya, H Seto
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 46 Issue 10 Pg. 1557-62 (Oct 1993) ISSN: 0021-8820 [Print] England
PMID8244883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Macrolides
  • quinolidomicin A2
  • quinolidomicin B1
  • quinolidomicin A1
Topics
  • Animals
  • Anti-Bacterial Agents (chemistry, isolation & purification, therapeutic use)
  • Antineoplastic Agents (chemistry, isolation & purification, therapeutic use)
  • Fermentation
  • Humans
  • Leukemia P388 (drug therapy)
  • Macrolides
  • Magnetic Resonance Spectroscopy
  • Mice
  • Micromonospora (chemistry)
  • Tumor Cells, Cultured (drug effects)

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