Abstract |
A case of transmission of a glioblastoma multiforme from the donor to a kidney transplant recipient in the absence of previous ventriculosystemic shunt is described. The recipient was a 48-year-old woman who developed a fever with no other associated symptoms 17 months posttransplant. Physical examination revealed a large nonpulsatile mass on the upper graft pole. Histopathologic examination showed a highly cellular neoplasm with fusiform and globoid cells, a high grade of nuclear pleomorphism and mitosis, necrosis with pseudopalisading, and vascular proliferation. Immunohistochemistry of the cells showed them to contain glial fibrillary acidic and S-100 proteins, consistent with a glioblastoma multiforme. We conclude that the risk of tumor transmission from donors with primary central nervous system tumors to kidney transplant recipients, is real and should be considered when evaluating a graft mass in such patients.
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Authors | F Val-Bernal, J C Ruiz, J G Cotorruelo, M Arias |
Journal | Human pathology
(Hum Pathol)
Vol. 24
Issue 11
Pg. 1256-9
(Nov 1993)
ISSN: 0046-8177 [Print] United States |
PMID | 8244327
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glial Fibrillary Acidic Protein
- S100 Proteins
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Topics |
- Adult
- Female
- Glial Fibrillary Acidic Protein
(analysis)
- Glioblastoma
(chemistry, etiology, pathology)
- Humans
- Immunohistochemistry
- Kidney Neoplasms
(chemistry, etiology, pathology)
- Kidney Transplantation
(adverse effects, pathology)
- Male
- Middle Aged
- S100 Proteins
(analysis)
- Tissue Donors
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