Abstract |
Anticonvulsant action of a new benzodiazepine, bretazenil (Ro 16-6028), was studied in 240 rats in five age groups: age 7, 12, 18, 25 and 90 days. Motor seizures induced by metrazol (pentamethylenetetrazol, PTZ, 100 mg/kg subcutaneously (s.c.) except for 18-day-old rats which received a dose of 90 mg/kg) served as a model. Animals were pretreated with Ro 16-6028 in doses of 0.001-0.1 mg/kg intraperitoneally (i.p.) 10 min before metrazol. Both types of metrazol-induced seizures, minimal (mMS, predominantly clonic with preserved righting ability) and major (MMS, generalized tonic-clonic), were suppressed by Ro 16-6028 in a dose-dependent manner. Major seizures were always more sensitive to Ro 16-6028 than were minimal seizures. The youngest rats exhibited maximal effects of Ro 16-6028 against major seizures. On the other hand, this drug increased the incidence of minimal seizures in 7- and 12-day-old rats, i.e., in age groups in which this type of seizure is rare under control conditions.
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Authors | H Kubová, J Rathouská, P Mares |
Journal | Epilepsia
(Epilepsia)
1993 Nov-Dec
Vol. 34
Issue 6
Pg. 1130-4
ISSN: 0013-9580 [Print] United States |
PMID | 8243368
(Publication Type: Journal Article)
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Chemical References |
- Benzodiazepinones
- Receptors, GABA
- bretazenil
- Pentylenetetrazole
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Topics |
- Adult
- Animals
- Benzodiazepinones
(pharmacology)
- Child
- Dose-Response Relationship, Drug
- Epilepsy
(chemically induced, prevention & control)
- Female
- Humans
- Injections, Intraperitoneal
- Kindling, Neurologic
- Male
- Pentylenetetrazole
- Rats
(growth & development)
- Receptors, GABA
(drug effects)
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