Abstract | BACKGROUND: METHODS: RESULTS:
Tumor volumes and weights were significantly reduced by treatment with RC-3095, compared with those of controls. In rats that received [D-Lys6]- LH-RH, there was a greater decrease in tumor weight and volume than that produced by RC-3095, and the weights of testes, ventral prostate, and seminal vesicles also were reduced. The combination of RC-3095 and [D-Lys6]- LH-RH had the greatest inhibitory effect on tumor growth. Histologic parameters demonstrated a significant increase of the ratio of apoptotic to mitotic indices in the groups treated with [D-Lys6]- LH-RH or the combination. Serum LH and testosterone levels were greatly depressed by [D-Lys6]- LH-RH or the combination. Specific high-affinity binding sites for bombesin/GRP, epidermal growth factor ( EGF), and insulin-like growth Factor I ( IGF-I) were found on the tumor membranes. The concentration of receptors for EGF was significantly reduced by treatment with the bombesin/GRP antagonist RC-3095. CONCLUSIONS:
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Authors | J Pinski, G Halmos, K Szepeshazi, A V Schally |
Journal | Cancer
(Cancer)
Vol. 72
Issue 11
Pg. 3263-70
(Dec 01 1993)
ISSN: 0008-543X [Print] United States |
PMID | 8242552
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Peptide Fragments
- Peptides
- Receptors, Bombesin
- bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-
- Gonadotropin-Releasing Hormone
- Testosterone
- LHRH, Lys(6)-
- Gastrin-Releasing Peptide
- ErbB Receptors
- Receptor, IGF Type 1
- Bombesin
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Topics |
- Adenocarcinoma
(drug therapy, pathology)
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bombesin
(administration & dosage, analogs & derivatives, antagonists & inhibitors, therapeutic use)
- Connective Tissue
(drug effects, pathology)
- ErbB Receptors
(drug effects)
- Gastrin-Releasing Peptide
- Gonadotropin-Releasing Hormone
(administration & dosage, analogs & derivatives, antagonists & inhibitors, therapeutic use)
- Male
- Mitosis
- Peptide Fragments
(administration & dosage, therapeutic use)
- Peptides
(administration & dosage, antagonists & inhibitors, therapeutic use)
- Prostatic Neoplasms
(drug therapy, pathology)
- Rats
- Rats, Inbred F344
- Rats, Inbred Strains
- Receptor, IGF Type 1
(drug effects)
- Receptors, Bombesin
(drug effects)
- Testosterone
(blood)
- Time Factors
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