Inhibition of reflex epilepsy by (+/-)-N-n-propylnorapomorphine.

Abstract

In baboons, Papio papio, spontaneously showing photosensitive epilepsy, myoclonic responses to intermittent photic stimulation were reduced or abolished for up to four hours by (+/-)-N-n-propylnorapomorphine (NPA) 0.05-0.2 mg/kg body weight, given i.v. In animals pretreated with allyglycine, 200 mg/kg, a transient abolition of myoclonic responses followed NPA, 0.2 mg/kg. In DBA/2 mice, seizures following auditory stimulation were attenuated or abolished by NPA 0.025-0.1 mg/kg given intraperitoneally (ED50 for abolition of clonic phase = 0.032 mg/kg). The ED50 for pentylenetetrazol seizures in MF 1 mice was not altered by NPA 0.25 mg/kg.

• Authors: C Ashton, G Anlezark, B Meldrum
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 39 Issue 2 Pg. 399-401 (Oct 1976) ISSN: 0014-2999 [Print] Netherlands
• PMID: 824145 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Apomorphine
• Pentylenetetrazole

Topics

• Animals
• Anticonvulsants
• Apomorphine (administration & dosage, analogs & derivatives, pharmacology)
• Female
• Haplorhini
• Male
• Mice
• Papio
• Pentylenetetrazole (antagonists & inhibitors)
• Photic Stimulation
• Reflex (drug effects)
• Seizures (prevention & control)