Phosphocitrate prevents disease progression in murine progressive ankylosis.

Abstract

OBJECTIVE:

Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression.

METHODS:

Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle.

RESULTS:

Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice.

CONCLUSION:

PC appears to inhibit disease progression in murine progressive ankylosis.

• Authors: H E Krug, M L Mahowald, P B Halverson, J D Sallis, H S Cheung
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 36 Issue 11 Pg. 1603-11 (Nov 1993) ISSN: 0004-3591 [Print] United States
• PMID: 8240437 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Citrates
• phosphocitrate

Topics

• Animals
• Ankylosis (drug therapy, pathology, prevention & control)
• Citrates (therapeutic use)
• Joint Diseases (prevention & control)
• Joints (pathology)
• Mice
• Mice, Inbred Strains