Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard reaction, in diabetic serum.

Abstract

3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic complications such as diabetic nephropathy by promoting the formation of advanced glycation end products.

• Authors: T Niwa, N Takeda, H Yoshizumi, A Tatematsu, M Ohara, S Tomiyama, K Niimura
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 196 Issue 2 Pg. 837-43 (Oct 29 1993) ISSN: 0006-291X [Print] United States
• PMID: 8240359 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Cross-Linking Reagents
• 3-deoxyglucose
• Deoxyglucose

Topics

• Adult
• Aged
• Biomarkers (blood)
• Cross-Linking Reagents
• Deoxyglucose (analogs & derivatives, blood)
• Diabetes Mellitus (blood)
• Diabetes Mellitus, Type 1 (blood)
• Diabetes Mellitus, Type 2 (blood)
• Diabetic Nephropathies (blood)
• Female
• Gas Chromatography-Mass Spectrometry (methods)
• Humans
• Maillard Reaction
• Male
• Middle Aged
• Reference Values