Abstract | BACKGROUND: Single-dose cefixime 400 mg orally is effective in the treatment of uncomplicated gonorrhea. However, lower doses of cefixime have not been studied, and the minimum effective single-dose regimen may risk selecting resistant strains of Neisseria gonorrhoeae. Therefore, we studied the efficacy of a lower dose of cefixime. OBJECTIVE: To assess the efficacy of 200 mg cefixime in the treatment of uncomplicated gonorrhea. METHODS: One hundred twenty-five patients (106 men, 19 women) with presumptive gonorrhea were treated with single doses of cefixime 200 mg orally in an open non-comparative study. Follow-up visits were scheduled for four to seven days after treatment. RESULTS: CONCLUSIONS:
Cefixime 200 mg in a single dose has substantial efficacy in the treatment of uncomplicated gonorrhea, enhancing confidence that use of 400 mg cefixime for gonorrhea has a low risk of selecting gonococci with clinically significant antibiotic resistance. However, the 200 mg dose should not be used for routine treatment.
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Authors | M S Verdon, J M Douglas Jr, S D Wiggins, H H Handsfield |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
1993 Sep-Oct
Vol. 20
Issue 5
Pg. 290-3
ISSN: 0148-5717 [Print] United States |
PMID | 8235928
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Bacterial Agents
- Cefixime
- Cefotaxime
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Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(administration & dosage, adverse effects, therapeutic use)
- Cefixime
- Cefotaxime
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Female
- Gonorrhea
(drug therapy)
- Humans
- Male
- Microbial Sensitivity Tests
- Neisseria gonorrhoeae
(drug effects)
- Rectal Diseases
(drug therapy, microbiology)
- Treatment Outcome
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