Plasma angiotensin I concentration and serum placental leucine aminopeptidase (P-LAP) activities in puerperal hypertension.

Abstract

To elucidate the involvement of angiotensin in puerperal hypertension with and without preeclampsia in the course of prior pregnancy, we measured plasma angiotensin I levels and serum placental leucine aminopeptidase (P-LAP) activities in several puerperal hypertensive patients. Placental leucine aminopeptidase (P-LAP) activities of puerperal hypertensive patients with severe preeclampsia during prior pregnancy were equal to or somewhat lower levels than those in normal puerperal women after a normal pregnancy. However, their angiotensin I levels were higher than those in normal puerperal women after a normal pregnancy. In puerperal hypertensive patients with and without preeclampsia during prior pregnancy, P-LAP activities tended to show much lower levels that those in normal puerperal women, while angiotensin I levels tended to show much higher levels than those in normal puerperal women, respectively. Since serum placental leucine aminopeptidase acts as an angiotensinase via degradation of angiotensin III (A-III), our present data suggest the involvement of angiotensin in puerperal hypertension.

• Authors: S Mizutani, Y Tomoda
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 81 Issue 3 Pg. 271-91 (Sep 1993) ISSN: 0034-5164 [Print] United States
• PMID: 8235062 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin I
• Captopril
• Leucyl Aminopeptidase
• Renin

Topics

• Adult
• Angiotensin I (blood)
• Captopril (therapeutic use)
• Female
• Humans
• Hypertension (blood, complications)
• Leucyl Aminopeptidase (blood, metabolism)
• Pre-Eclampsia (blood, drug therapy)
• Pregnancy
• Pregnancy Complications, Cardiovascular (blood)
• Puerperal Disorders (blood)
• Renin (blood)