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Low-dose/long-term erythromycin for treatment of bronchiolitis obliterans organizing pneumonia (BOOP).

Abstract
Bronchiolitis obliterans organizing pneumonia (BOOP) is a pathologic entity characterized by intraluminal fibrosis of distal air spaces. Corticosteroids have been widely used for the treatment of this condition, and most patients showed a dramatic response to it. However, long-term treatment with corticosteroids, which often increases the risk of several undesirable side-effects, is usually required because a relapse tends to occur soon after termination of treatment. We administered erythromycin (EM) at low-dose (600 mg daily) for 3-4 months to 6 patients with BOOP, and obtained a good clinical, radiological, and physiological improvement. This suggests that EM can be successfully used, instead of corticosteroids, in the treatment of BOOP.
AuthorsY Ichikawa, H Ninomiya, M Katsuki, M Hotta, M Tanaka, K Oizumi
JournalThe Kurume medical journal (Kurume Med J) Vol. 40 Issue 2 Pg. 65-7 ( 1993) ISSN: 0023-5679 [Print] Japan
PMID8231065 (Publication Type: Journal Article)
Chemical References
  • Erythromycin
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bronchiolitis Obliterans (drug therapy)
  • Erythromycin (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Middle Aged
  • Pneumonia (drug therapy)

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