Abstract |
Plasma concentrations of febantel and its major metabolites fenbendazole, oxfendazole and oxfendazole sulphone were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection with 50,000 L3 larvae of Ostertagia circumcincta or Trichostrongylus colubriformis. The febantel concentrations were always very low and only in a few samples higher than the detection limit. The mean decrease in AUC for the three metabolites for the infected sheep in comparison to the parasite naïve sheep was 13.9% +/- 4.1% (mean +/- SEM) and 23.7% +/- 5.3% in the O. circumcincta infected and the T. colubriformis infected lambs respectively. This reduction was only significant for the T. colubriformis infected group. In order to determine a more complete pharmacokinetic profile, febantel was injected intravenously at a dose of 2.5 mg/kg in a further study.
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Authors | M Debackere, J Landuyt, J Vercruysse, Q McKellar |
Journal | Journal of veterinary pharmacology and therapeutics
(J Vet Pharmacol Ther)
Vol. 16
Issue 3
Pg. 261-74
(Sep 1993)
ISSN: 0140-7783 [Print] England |
PMID | 8230397
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthelmintics
- Benzimidazoles
- Guanidines
- Fenbendazole
- oxfendazole
- febantel
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Topics |
- Administration, Oral
- Animals
- Anthelmintics
(pharmacokinetics)
- Benzimidazoles
(pharmacokinetics)
- Biological Availability
- Chromatography, High Pressure Liquid
(veterinary)
- Feces
(parasitology)
- Fenbendazole
(pharmacokinetics)
- Guanidines
(pharmacokinetics)
- Injections, Intravenous
- Male
- Ostertagiasis
(metabolism, veterinary)
- Parasite Egg Count
(veterinary)
- Sheep
- Sheep Diseases
(metabolism, parasitology)
- Trichostrongylosis
(metabolism, veterinary)
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