Abstract |
In this study, porcine pulmonary artery segments (intact or denuded) and bronchial segments (with or without epithelium) were tested in organ bath. Hypoxia caused a bronchial epithelium dependent relaxation of intact or denuded pulmonary artery preconstricted with phenylephrine. Constriction in intact pulmonary artery coated with epithelium denuded bronchus was observed during hypoxia. The bronchial epithelium-dependent relaxation could be inhibited by indomethacin but not be blocked by the following agents: atropine, propranolol, gossypol, methylene blue and chlorpheniramine. The results suggested that HPV was endothelium-dependent. Hypoxia could cause the production of an epithelium-derived relaxing factor ( EpDRF), which acted directly on smooth muscle. The effect of EpDRF was not mediated by pulmonary endothelium, but might be related to arachidonic acid cyclooxygenase pathway.
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Authors | W H Wang, D X Wang |
Journal | Journal of Tongji Medical University = Tong ji yi ke da xue xue bao
(J Tongji Med Univ)
Vol. 13
Issue 2
Pg. 84-7
( 1993)
ISSN: 0257-716X [Print] China |
PMID | 8230361
(Publication Type: Journal Article)
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Chemical References |
- Biological Factors
- epithelium-derived relaxant factor
- Indomethacin
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Topics |
- Animals
- Biological Factors
(metabolism, physiology)
- Bronchi
(cytology, metabolism)
- Cell Hypoxia
(physiology)
- Epithelium
(metabolism)
- In Vitro Techniques
- Indomethacin
(pharmacology)
- Male
- Pulmonary Artery
(physiology)
- Swine
- Vasoconstriction
(drug effects)
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