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The identification of 5-hydroxy-L-norvaline in cultures of pyridoxine auxotrophs of Escherichia coli B.

Abstract
Gc-ms and hplc have been employed to identify 5-hydroxy-L-norvaline (L-2-amino-5-hydroxypentanoic acid) in the culture fluids of pyridoxine-starved cultures of two pyridoxine auxotrophs of Escherichia coli B. The production of 5-hydroxynorvaline is shown to be secondary to pyridoxine starvation of the cultures, and the quantities of 5-hydroxynorvaline are similar to those of the common protein amino acids present in these cultures. This is the first time that 5-hydroxynorvaline has been identified as a product of bacterial metabolism.
AuthorsR E Hill, R L White, K C Smith
JournalJournal of natural products (J Nat Prod) Vol. 56 Issue 8 Pg. 1246-54 (Aug 1993) ISSN: 0163-3864 [Print] United States
PMID8229010 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acids
  • Culture Media
  • 2-amino-5-hydroxyvaleric acid
  • Pyridoxine
Topics
  • Amino Acids (analysis, metabolism)
  • Culture Media (chemistry)
  • Escherichia coli (chemistry, genetics, growth & development)
  • Mutation
  • Pyridoxine (metabolism)

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