Associations between polymorphic variety and disease susceptibility in two New Guinea populations.

Abstract

During the Australian/British IBP studies on KarKar Island and at Lufa in the Eastern Highlands, Papua New Guinea, information was collected on the epidemiology and genetic constitution of the same subjects. Advantage of this special situation has been taken to determine whether any associations exist between the genetic markers and the disease states. Those found and which appear real include Rhesus D(u) with proteinuria; MN with splenomegaly and hepatomegaly; Ss with parotid enlargement; acid phosphatase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogense and haemoglobin J- Tongariki with presence of malarial parasites; phosphoglucomutase with proteinuria and parotid enlargement; haptoglobin with proteinuria and with splenomegaly and hepatomegaly. These associations are discussed in terms of the probabilities of their arising from heterogeneity in population structure, linkage disequilibrium and pleiotropy.

• Authors: G A Harrison, A J Boyce
• Journal: Annals of human biology (Ann Hum Biol) Vol. 3 Issue 3 Pg. 253-67 (May 1976) ISSN: 0301-4460 [Print] England
• PMID: 822772 (Publication Type: Journal Article)

Chemical References

• Blood Group Antigens
• Enzymes
• Haptoglobins
• MNSs Blood-Group System
• Rh-Hr Blood-Group System
• Phosphogluconate Dehydrogenase
• Glucosephosphate Dehydrogenase
• Acid Phosphatase
• Phosphoglucomutase

Topics

• Acid Phosphatase (blood)
• Blood Group Antigens
• Enzymes (blood)
• Female
• Glucosephosphate Dehydrogenase (blood)
• Haptoglobins
• Hepatomegaly (genetics)
• Humans
• MNSs Blood-Group System
• Malaria (enzymology)
• Male
• Morbidity
• New Guinea
• Parotitis (enzymology, genetics)
• Phosphoglucomutase (blood)
• Phosphogluconate Dehydrogenase (blood)
• Polymorphism, Genetic
• Proteinuria (enzymology, genetics)
• Rh-Hr Blood-Group System
• Sex Factors
• Splenomegaly (genetics)