HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Successful treatment of retained placenta with umbilical cord injections of collagenase in cows.

Abstract
Fetal membranes usually are released from the uterus between 2 and 6 postpartum hours. However, in a substantial percentage of cows (11%), fetal membranes are retained for several days. In part, failure of collagen breakdown seems to be related to retention of fetal membranes. Injections of 200,000 U of bacterial collagenase in 1,000 ml of physiologic saline solution via umbilical arteries (1 or 2) between 24 and 72 hours of retention caused release of retained fetal membranes in 23 of 27 cows (85%) with noninduced retained fetal membranes and in 10 of 14 cows (71%) with experimentally induced retained fetal membranes, within 36 hours after injection. Controls (n = 36) did not release retained fetal membranes within this time. Injections of collagenase via a jugular vein (2.2 x 10(6) U in 1,000 ml of physiologic saline solution), administered over a 30-minute period, caused release of retained fetal membranes within 36 hours in 3 of 6 cows with experimentally induced retained fetal membranes. Clinical complications did not follow treatments with collagenase. Umbilical injections of bacterial collagenase were highly effective in the treatment of retained fetal membranes in cows. The procedure is simple, safe, affordable, and can be completed in 25 minutes.
AuthorsH Eiler, F M Hopkins
JournalJournal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 203 Issue 3 Pg. 436-43 (Aug 01 1993) ISSN: 0003-1488 [Print] United States
PMID8226224 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Collagenases
Topics
  • Animals
  • Cattle
  • Cattle Diseases (drug therapy)
  • Collagenases (administration & dosage, therapeutic use)
  • Female
  • Infusions, Intravenous (veterinary)
  • Injections, Intra-Arterial (veterinary)
  • Placenta Diseases (drug therapy, veterinary)
  • Pregnancy
  • Puerperal Disorders (drug therapy, veterinary)
  • Umbilical Arteries

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: