Topical tromantadine in the treatment of genital herpes. A double-blind placebo controlled study.

Abstract

A randomised double-blind placebo controlled trial was performed to assess the efficacy and safety of tromantadine ointment 1% in male patients with genital herpes. 45 patients with penile genital herpes of less than three days duration were randomised to local treatment with tromantadine ointment 1% or placebo (ointment base alone) five times daily up to 12 days. No difference in time of healing could be detected between the two groups (p = 1.0). Both the objective signs (vesicles, pustules, ulceration, and glandular swelling) and the subjective symptoms (itching, burning, pain and dysuria) all diminished simultaneously in the two groups.

• Authors: C S Petersen, K Weismann, C Avnstorp, L P Rasmussen, H Fogh, G Tikjøb
• Journal: Danish medical bulletin (Dan Med Bull) Vol. 40 Issue 4 Pg. 506-7 (Sep 1993) ISSN: 0907-8916 [Print] Denmark
• PMID: 8222773 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiviral Agents
• Amantadine
• tromantadine

Topics

• Administration, Topical
• Adult
• Amantadine (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Antiviral Agents (adverse effects, therapeutic use)
• Double-Blind Method
• Herpes Genitalis (drug therapy)
• Humans
• Male
• Penile Diseases (drug therapy, microbiology)