HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clinical implication and prognostic significance of small lymphoma cells in the peripheral blood and bone marrow of B-cell non-Hodgkin's lymphomas.

Abstract
It seems possible that small lymphoma cells (SLC) may have a role even in aggressive B-cell non-Hodgkin's lymphoma (B-NHL) such as large-cell lymphoma. However, SLC are often difficult to distinguish morphologically from normal or reactive small lymphocytes. In this study, we used a flowcytometric technique (kappa-lambda imaging; KLI) for detection of SLC. Peripheral blood (PB) and bone marrow (BM) samples taken from 41 patients with surface immunoglobulin positive (sIg+) B-NHL were analysed. SLC were detected in about 90% (37/41) of the untreated patients when either PB or BM was analysed by KLI. The presence of SLC correlated well with disease activity. However, a few SLC were present even in the PB (16%) or BM (27%) of the 31 patients who achieved complete remission, indicating that minimal residual disease (MRD) was present. In some cases, the reappearance of SLC in the PB or BM preceded clinical relapse. Furthermore, the initial volume of SLC, particularly in the BM, tended to be related to the prognosis (P = .068). These results suggest that the detection of SLC by KLI may be helpful not only for the screening and clinical staging of sIg+ B-NHL, but also for monitoring disease activity and detecting MRD. Moreover, the volume of SLC in the BM may be a useful predictor of prognosis.
AuthorsM Nakano, Y Kuriyama, Y Kawanishi, K Toyama
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 11 Issue 1-2 Pg. 119-27 (Sep 1993) ISSN: 1042-8194 [Print] United States
PMID8220145 (Publication Type: Journal Article)
Chemical References
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • Receptors, Antigen, B-Cell
Topics
  • Bone Marrow (pathology)
  • Flow Cytometry
  • Humans
  • Immunoglobulin kappa-Chains (analysis)
  • Immunoglobulin lambda-Chains (analysis)
  • Lymphoma, B-Cell (diagnosis, mortality, pathology)
  • Neoplastic Cells, Circulating
  • Prognosis
  • Receptors, Antigen, B-Cell (analysis)
  • Survival Rate

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: