Effect of treatment with liu-jun-zi-tang (TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients.

Abstract

The effects of treatment with the Chinese herbal medicine Liu-Jun-Zi-Tang (TJ-43) on gastric emptying and gastrointestinal symptoms were investigated in 42 patients with chronic idiopathic dyspepsia. By random allocation, 22 patients received oral treatment with 2.5 g TJ-43 three times daily, and 20 patients received placebo. Gastric emptying was measured by the acetaminophen absorption method. After 7 days of treatment, gastric emptying was significantly accelerated and gastrointestinal symptoms were significantly reduced in patients treated with TJ-43. Placebo treatment produced no significant effects. These findings indicate that TJ-43 had a prokinetic action on gastric emptying and that it was useful in treating chronic dyspepsia.

• Authors: M Tatsuta, H Iishi
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 7 Issue 4 Pg. 459-62 (Aug 1993) ISSN: 0269-2813 [Print] England
• PMID: 8218760 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Drugs, Chinese Herbal
• liu-jun-zi-tang

Topics

• Adult
• Chronic Disease
• Drugs, Chinese Herbal (therapeutic use)
• Dyspepsia (drug therapy, physiopathology)
• Female
• Gastric Emptying (drug effects)
• Gastrointestinal Diseases (drug therapy, physiopathology)
• Humans
• Male
• Middle Aged