Nucleotide and deduced amino acid sequence of human ribosomal protein L18.

Abstract

Ribosomal protein L18 mRNA is overexpressed in human colorectal cancer compared to normal colon tissue. We report the nucleotide sequence of human L18 cDNA derived from a normal colon source. There were no mutational changes in segments of L18 cDNA derived from two tumor sources. The L18 cDNA was 690 base pairs long and predicts a single open reading frame of 564 nucleotides, encoding 188 amino acids with a M(r) = 21,621, it is homologous to rat L18 and Xenopus laevis L14.

• Authors: M Puder, G F Barnard, R J Staniunas, G D Steele Jr, L B Chen
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1216 Issue 1 Pg. 134-6 (Oct 19 1993) ISSN: 0006-3002 [Print] Netherlands
• PMID: 8218404 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Complementary
• RNA, Messenger
• Ribosomal Proteins
• ribosomal protein L18

Topics

• Amino Acid Sequence
• Base Sequence
• Colon (metabolism)
• Colorectal Neoplasms (genetics)
• DNA, Complementary (chemistry)
• Gene Expression
• Gene Library
• Humans
• Molecular Sequence Data
• RNA, Messenger (isolation & purification)
• Ribosomal Proteins (genetics)
• Sequence Homology, Nucleic Acid