Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice.

Abstract

Aminophylline (theophylline2.ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous theophylline/kg). In contrast, 8-(p-sulfophenyl)theophylline (a theophylline derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.

• Authors: K Borowicz, M Kozicka, Z Kleinrok, S J Czuczwar
• Journal: Journal of neural transmission. General section (J Neural Transm Gen Sect) Vol. 93 Issue 2 Pg. 157-63 ( 1993) Austria
• PMID: 8217053 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Aminophylline
• Valproic Acid
• Phenytoin
• 8-(4-sulfophenyl)theophylline
• Theophylline
• Phenobarbital

Topics

• Aminophylline (pharmacology)
• Animals
• Anticonvulsants (antagonists & inhibitors, pharmacology)
• Dose-Response Relationship, Drug
• Electroshock
• Male
• Mice
• Phenobarbital (antagonists & inhibitors, pharmacology)
• Phenytoin (antagonists & inhibitors, pharmacology)
• Seizures (prevention & control)
• Theophylline (analogs & derivatives, pharmacology)
• Valproic Acid (antagonists & inhibitors, pharmacology)