Abstract |
Aminophylline (theophylline2.ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous theophylline/kg). In contrast, 8-(p-sulfophenyl)theophylline (a theophylline derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.
|
Authors | K Borowicz, M Kozicka, Z Kleinrok, S J Czuczwar |
Journal | Journal of neural transmission. General section
(J Neural Transm Gen Sect)
Vol. 93
Issue 2
Pg. 157-63
( 1993)
Austria |
PMID | 8217053
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anticonvulsants
- Aminophylline
- Valproic Acid
- Phenytoin
- 8-(4-sulfophenyl)theophylline
- Theophylline
- Phenobarbital
|
Topics |
- Aminophylline
(pharmacology)
- Animals
- Anticonvulsants
(antagonists & inhibitors, pharmacology)
- Dose-Response Relationship, Drug
- Electroshock
- Male
- Mice
- Phenobarbital
(antagonists & inhibitors, pharmacology)
- Phenytoin
(antagonists & inhibitors, pharmacology)
- Seizures
(prevention & control)
- Theophylline
(analogs & derivatives, pharmacology)
- Valproic Acid
(antagonists & inhibitors, pharmacology)
|