Angiotensin-converting enzyme (
ACE) inhibitors have been reported to cause
angioedema. The purpose of this study was to establish what proportion of patients who present to the emergency department (ED) with
angioedema were concomitantly taking any of the
ACE inhibitors and to show how this group differed in presentation and response to treatment from the larger population of patients with non-
ACE inhibitor-related
angioedema. An 8-year retrospective chart review of all patients with the diagnosis of
angioedema observed from January 1, 1984 to December 31, 1991 was undertaken in the ED of an urban teaching hospital. Forty-nine patients ranging from 12 to 88 years of age with symptoms and physical examination that was consistent with the diagnosis of
angioedema were entered onto the study. Twelve cases of
ACE inhibitor-related
angioedema were identified, all occurring in the last 4 years of the review, and when compared with the non-
ACE inhibitor-related group were older (mean age, 63.3 vs 43.0 years), had less of an allergic history (0% vs 49%; P = .013), but demonstrated the same severity of symptoms and response to medical
therapy. No case required an artificial or surgical airway.
ACE inhibitor related
angioedema is becoming a common type of
angioedema observed in this ED. These patients are older and free of other allergic disease and respond well to traditional
therapy.