Abstract | OBJECTIVE: DESIGN: A 12-week, double-blind, randomized controlled trial. SETTING: A university otolaryngology clinic. PATIENTS: Ninety-two subjects with severe chronic tinnitus: 38 with current major depression and 54 with depressive symptoms and significant tinnitus-related disability. INTERVENTION:
Nortriptyline (maintained at 50 to 150 mg/mL for 6 weeks) or placebo. MAIN OUTCOME MEASURES: Hamilton Depression Rating Scale, Tinnitus Disability Measures, and Audiometric Measures. RESULTS:
Nortriptyline was superior to placebo by multivariate analysis of covariance for depression (10.6 vs 14.3 final Hamilton Depression score), for tinnitus-related disability (1.8 vs 2.4 final MPI Tinnitus Interference), and tinnitus loudness (13.6 vs 20.0 dB final loudness match [in worst ear at tinnitus frequency]). When major depression and depressive symptoms groups were considered separately, nortriptyline was superior to placebo on these same measures but differences did not achieve statistical significance. CONCLUSIONS: The antidepressant nortriptyline decreases depression, functional disability, and tinnitus loudness associated with severe chronic tinnitus. What appears to be irreversible disability of otologic origin may, in part, be reversible disability of psychiatric origin.
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Authors | M Sullivan, W Katon, J Russo, R Dobie, C Sakai |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 153
Issue 19
Pg. 2251-9
(Oct 11 1993)
ISSN: 0003-9926 [Print] United States |
PMID | 8215728
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Aged
- Audiometry, Pure-Tone
- Chronic Disease
- Depression
(complications, drug therapy)
- Depressive Disorder
(complications, drug therapy)
- Disabled Persons
(psychology)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Nortriptyline
(therapeutic use)
- Severity of Illness Index
- Tinnitus
(drug therapy, psychology)
- Treatment Outcome
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