HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Photodynamic therapy of brain tumours.

Abstract
Photodynamic therapy is a binary treatment combining the selective uptake of a photosensitizer into a tumour followed by irradiation of the tumour with light of the appropriate wavelength to cause activation of the sensitizer as selective tumour kill. Photodynamic therapy has been extensively investigated in laboratory studies in the treatment of cerebral tumours and has been utilised in clinical trials to treat a variety of tumours including cerebral glioma. The clinical trials have usually used PDT as an adjuvant therapy following tumour resection but studies are being undertaken to use the treatment in combination with stereotactic techniques. The photosensitizer haematoporphyrin derivative (HpD) has been shown to be selectively localised into all grades of glioma with a direct correlation between the grade of glioma and HpD level in the tumour. The levels were highest in the glioblastoma multiforme (mean uptake of 5.9 micrograms HpD/g tumour wet weight) and lower in the intermediate grade anaplastic astrocytoma (2.4 micrograms/g) and low grade astrocytoma (1.6 micrograms/g). Uptake into normal brain tissue taken from HpD sensitized patients was 0.2 microgram/g. HpD was also localised into the brain adjacent to the tumour region.
AuthorsA H Kaye, J S Hill
JournalAnnals of the Academy of Medicine, Singapore (Ann Acad Med Singap) Vol. 22 Issue 3 Suppl Pg. 470-81 (May 1993) ISSN: 0304-4602 [Print] Singapore
PMID8215203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Topics
  • Adult
  • Animals
  • Brain Neoplasms (drug therapy, mortality)
  • Cell Survival (drug effects)
  • Glioma (drug therapy, mortality)
  • Hematoporphyrin Photoradiation (methods)
  • Humans
  • Neoplasm Recurrence, Local (drug therapy, mortality)
  • Neoplasm Transplantation
  • Survival Rate

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: