Restoration of gallbladder contractility after withdrawal of long-term octreotide therapy in acromegalic patients.
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| Abstract |
We sought to examine how the discontinuation of octreotide in long-term octreotide-treated acromegalic patients affects the well-documented side-effect of cholelithiasis. In 14 acromegalic patients, serum growth hormone levels, insulin-like growth factor I levels and percentage of relative gallbladder contractility were measured prior to and after the discontinuation of octreotide. Compared to pretreatment values, the basal growth hormone and 5-h growth hormone profiles were 36% and 24%, and 60% and 56% at the end of 1 and 2 weeks, respectively. Octreotide was found to be eliminated completely from the serum within 3 days after its withdrawal. In all of six patients who did not develop gallstones, the percentage relative gallbladder contractility normalized within 1 week. In eight patients who developed gallstones, four of them had restoration of normal contractility within 2 weeks. Our results show that upon withdrawal of octreotide, gallbladder contractility returns to normal while growth hormone suppression persists for a longer period of time. Therefore, discontinuation of octreotide therapy may allow for the clearance of stagnated bile and hence decrease the incidence of cholelithiasis in acromegalic patients receiving long-term therapy.
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| Authors | Y F Shi, X F Zhu, A G Harris, J X Zhang, J Y Deng |
| Journal | Acta endocrinologica (Acta Endocrinol (Copenh)) Vol. 129 Issue 3 Pg. 207-12 (Sep 1993) ISSN: 0001-5598 [Print] Denmark |
| PMID | 8212985 (Publication Type: Journal Article) |
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