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Formation of 18-deoxy-19-noraldosterone by a human aldosterone-producing adenoma.

Abstract
The recently synthesized 18-deoxy-19-noraldosterone is a potent aldosterone antagonist. In the present study we demonstrate the in vitro formation of 18-deoxy-19-noraldosterone from 19-noraldosterone in a human aldosterone-producing adenoma and normal adrenal tissue. The metabolite was isopolar, cochromatographed with the authentic standard on high-performance liquid chromatography, and the identity was further analyzed by mass spectrometry. The possible role of 18-deoxy-19-noraldosterone in primary aldosteronism is also discussed.
AuthorsY Takeda, K Iki, I Miyamori, R Takeda
JournalSteroids (Steroids) Vol. 58 Issue 6 Pg. 282-5 (Jun 1993) ISSN: 0039-128X [Print] United States
PMID8212075 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Mineralocorticoid Receptor Antagonists
  • 19-norcorticosterone
  • Aldosterone
  • Corticosterone
Topics
  • Adenoma (metabolism)
  • Adrenal Gland Neoplasms (metabolism)
  • Aldosterone (biosynthesis)
  • Chromatography, High Pressure Liquid
  • Corticosterone (analogs & derivatives, biosynthesis)
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Mineralocorticoid Receptor Antagonists (metabolism)

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