[Platelet function after allogeneic bone marrow transplantation in Wiskott-Aldrich syndrome].

Abstract

PURPOSE:

To assess the platelet characteristics and functionalism in the Wiskott-Aldrich syndrome (WAS) after allogeneic BMT using cyclophosphamide and busulphan for conditioning.

MATERIAL AND METHODS:

Two WAS patients underwent allogeneic BMT. Platelet aggregation was studied prior to and after BMT, along with the intraplatelet amount of ADP and ATP.

RESULTS:

Platelet count, size and aggregation wholly recovered after BMT. The post-transplant content of platelet nucleotides was normal.

CONCLUSIONS:

Platelet function can be totally restored with cyclophosphamide/busulphan conditioned BMT in WAS. Platelet defects in this disease are due to defective thrombopoiesis.

• Authors: M Megido, J M Cesar, M S Maldonado, E Otheo, A Muñoz, J L Navarro
• Journal: Sangre (Sangre (Barc)) Vol. 38 Issue 3 Pg. 233-4 (Jun 1993) ISSN: 0036-4355 [Print] Spain
• Vernacular Title: Estudio de la función plaquetaria después del trasplante alogénico de medula ósea en el síndrome de Wiskott-Aldrich.
• PMID: 8211550 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclophosphamide
• Busulfan

Topics

• Blood Platelets (physiology)
• Bone Marrow Purging
• Bone Marrow Transplantation
• Busulfan
• Cell Size
• Child, Preschool
• Cyclophosphamide
• Graft Survival
• Humans
• Platelet Aggregation
• Platelet Count
• Postoperative Period
• Wiskott-Aldrich Syndrome (blood, surgery)