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Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels.

Abstract
Isolated endothelium-denuded segments of the human internal thoracic artery (ITA) and saphenous vein (SV) have been used for characterization of vasoinhibitory effects of the chromostatin (hChs) sequence of human chromogranin A (CGA124-143). In SV preincubation with hChs inhibited the response to depolarizing high K+ in Ca(2+)-free medium in a concentration dependent manner (EC50 approximately 2 nM). At 200 nM hChs the tension response to high K+ (80 mM) was inhibited by 44% (n = 8) and the tension response to noradrenaline (2.6 microM) was inhibited by 20% (n = 6), but the tension response to endothelin-1 (65 nM) (ET-1) was not affected. In ITA no effect of hChs was observed on tension response to K+ or ET-1 in Ca(2+)-free medium. On the other hand, in Ca(2+)-containing medium the tension evoked by 65 nM ET-1 was no longer sustained in segments preincubated with 200 nM hChs and declined spontaneously to 76 +/- 12% (n = 6) of maximal tension after 6 min. A vascular function for the Chs sequence of the human CGA is thus indicated, inhibiting different components of vasoconstrictor responses in the human SV and ITA segments.
AuthorsS Aardal, E Galindo, D Aunis, K B Helle
JournalRegulatory peptides (Regul Pept) Vol. 47 Issue 1 Pg. 25-32 (Aug 13 1993) ISSN: 0167-0115 [Print] Netherlands
PMID8210519 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chromogranin A
  • Chromogranins
  • Endothelins
  • Peptide Fragments
  • chromostatin
  • Calcium
Topics
  • Calcium (metabolism)
  • Chromogranin A
  • Chromogranins (physiology)
  • Endothelins (antagonists & inhibitors)
  • Endothelium, Vascular (physiology)
  • Humans
  • In Vitro Techniques
  • Muscle Contraction (physiology)
  • Muscle, Smooth, Vascular (physiology)
  • Peptide Fragments (physiology)
  • Saphenous Vein
  • Thoracic Arteries

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