Prevention and treatment of ocular inflammation with a new class of non-steroidal anti-inflammatory agents.

Abstract

New non-steroidal anti-inflammatory agents (NSAIAs) were tested on lens protein-, endotoxin- and interleukin-1-induced ocular inflammation. It was found that most NSAIAs, including REV 5901, mefenamic acid, indomethacin, CK-17 and CK-102, inhibited lens protein-induced inflammation. Endotoxin induced inflammation indirectly through the release of IL-1 which was inhibited by fewer agents, including CK-17, CK-102 and prednisolone. However, the direct effect of IL-1 can only be suppressed by CK-17 and prednisolone. Therefore, CK-17 could become an important NSAIA which acts similarly to corticosteroids yet produces no steroidal side effects. CK-17 was different from most NSAIAs as it affected little, if any, arachidonate metabolism. Most importantly, CK-17 was found to be 2-fold more potent than prednisolone in inhibiting IL-1-induced uveitis, while no side effects were noted at doses tested to date.

• Authors: G C Chiou, Q S Yao, M S Chang, T Okawara
• Journal: Journal of ocular pharmacology (J Ocul Pharmacol) Vol. 10 Issue 1 Pg. 335-47 ( 1994) ISSN: 8756-3320 [Print] United States
• PMID: 8207338 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Crystallins
• Leukotrienes
• Prostaglandins
• Prednisolone

Topics

• Animals
• Anterior Eye Segment (metabolism)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Chemotaxis, Leukocyte
• Crystallins
• Female
• Leukocytes
• Leukotrienes (biosynthesis)
• Male
• Prednisolone (therapeutic use)
• Prostaglandins (biosynthesis)
• Rabbits
• Rats
• Rats, Sprague-Dawley
• Retina (metabolism)
• Uveitis (chemically induced, drug therapy, prevention & control)