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Patients with renal cancer have a larger proportion of high-density blood monocytes with increased lucigenin-enhanced chemiluminescence.

Abstract
The production of oxygen metabolites is probably important in cancer cell killing. The production of the superoxide anion, O2-, can be measured by lucigenin-enhanced chemiluminescence (Cl). Previous studies have shown that whole-blood lucigenin-enhanced Cl is increased in cancer patients and that this increase is related to blood monocyte activity. The present investigation confirmed these findings and showed that whole-blood lucigenin-enhanced Cl was elevated in 17 patients with renal cell adenocarcinoma (P < 0.001). The activity of the monocytes was studied more in detail, whereby monocytes were separated into different populations based upon differences in densities, i.e., high-density and low-density monocytes. The cancer patients had a significantly larger proportion of high-density monocytes (P < 0.05) than controls. The lucigenin-enhanced Cl of purified high-density monocytes in controls was significantly higher than that of low-density monocytes (P < 0.01). The authors conclude that the increase in the lucigenin-enhanced Cl of whole blood observed in cancer patients may partly reflect the increased activity of a larger proportion of high-density monocytes in these patients.
AuthorsA Trulson, S Nilsson, E Brekkan, P Venge
JournalInflammation (Inflammation) Vol. 18 Issue 1 Pg. 99-105 (Feb 1994) ISSN: 0360-3997 [Print] United States
PMID8206648 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acridines
  • Superoxides
  • 10,10'-dimethyl-9,9'-biacridinium
Topics
  • Acridines
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Cell Count
  • Carcinoma, Renal Cell (blood)
  • Female
  • Humans
  • Luminescent Measurements
  • Male
  • Middle Aged
  • Monocytes
  • Oxidation-Reduction
  • Superoxides (metabolism)

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